Nicox, Ironwood to Collaborate on Novel Ophthalmic Treatments

June 15, 2018: By Joan McKenna

France-based Nicox has formed a research collaboration with Ironwood Pharmaceuticals that will combine Ironwood’s expertise in soluble guanylate cyclase (sGC) with Nicox’s proprietary nitric oxide (NO)-donating research platform to generate novel ophthalmic treatments.

Ironwood, of Cambridge, Massachusetts, co-markets with Allergan a product called Linzess (linaclotide), a guanylate cyclase‐C agonist to treat irritable bowel syndrome with constipation and chronic idiopathic constipation.

Under the Nicox/Ironwood collaboration, each company will be responsible for its own associated costs, and the companies may hold discussions over Nicox’ further development of any identified product candidate.

Nicox currently has two products with US approval: Vyzulta, licensed worldwide to Bausch + Lomb, and Zerviate, licensed in the US to Eyevance.

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