Tivanisiran is Generic Name for Sylentis’ Dry Eye Candidate

November 10, 2017: By Joan McKenna

Sylentis logoThe international nonproprietary, or generic, name for Sylentis’ SYL1001 candidate to treat dry eye disease will be tivanisiran.

The World Health Organization has approved the name, Sylentis announced Oct. 19.

Tivanisiran, based on genetic silencing technology through RNA interference (RNAi), is self-administered topically.

A Phase III trial, called HELIX, is being carried out in more than 30 hospitals in Spain, Germany, Estonia, Portugal, and Italy to evaluate tivanisiran’s efficacy in treating the signs and symptoms of dry eye in 300 patients.

The company, located in Madrid, is developing similar compounds for degenerative retinal diseases involving neovascularization.

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