Genentech’s Lampalizumab Fails Second Phase III Study in Geographic Atrophy

November 17, 2017: By Joan McKenna

Genentech’s lampalizumab failed to meet its primary endpoint in its second Phase III clinical trial in geographic atrophy, and the company will not pursue US approval for the indication.

San Francisco-based Genentech, part of the Roche Group, announced the results Nov. 9.

The trial was a double-masked, randomized, global study evaluating a 10 mg dose of lampalizumab administered every four or six weeks by intravitreal injection versus sham.

Lampalizumab failed to reduce mean change in GA lesion area compared with sham at one year. The results were similar to those of the first Phase III study released in September.

Lampalizumab is an antigen-binding fragment of a humanized monoclonal antibody directed against complement factor D.

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