Researchers Show Eye Drop Vehicle Can Deliver Anti-VEGF to Retina

July 27, 2018: By Joan McKenna

Scientists have shown their drug delivery vehicle effectively delivers Avastin and Lucentis to the back of the eye in rabbits and pigs, the UK’s University of Birmingham announced July 23. The research was led by Felicity de Cogan, PhD.

The team is now working with Macregen, of San Jose, California, which has licensed the technology, to develop therapies for age-related macular degeneration and other eye diseases.

Macregen’s own drug candidate, Mitia, is intended to remove and/or clear accumulated lipids under the macula that are the main component of drusen deposits typically observed in patients with dry AMD.

Macregen says it envisions Mitia being used in combination with anti-VEGF drugs that are designed to treat neovascular AMD. Thus, both the removal of lipid deposits and the inhibition of neovascular complications may be accomplished concurrently or sequentially.

Cogan’s team used a cell-penetrating peptide to deliver drugs to the back of the eye.

The combined team is now expediting proof of concept studies and says clinical trials could start as early as spring 2019.

Results of the rabbit and pig study were published under an open access license in the July 2018 issue of IOVS.


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